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Anabolic Steroids

Background: Anabolic steroids are synthetic derivatives of male hormone testosterone that mimic
its effects on muscle building and fat burning.

Use: Commonly used by athletes, bodybuilders, and
individuals seeking to enhance physical appearance and athletic performance.
Often abused for prolonged periods, leading to significant health risks.

# Anabolic Steroids: A Comprehensive Overview from StatPearls NCBI Bookshelf

Anabolic steroids have a rich history rooted in their initial use
as synthetic compounds designed to mimic testosterone’s
muscle-building effects. Over time, their applications
expanded beyond mere muscle growth, leading to clinical uses in treating conditions like muscle wasting and certain metabolic disorders.

## Account
The development of anabolic steroids began with early experiments by scientists like Albert Hofmann, who synthesized andropaustrans-ene,
one of the earliest anabolic compounds. These early iterations were later
refined into more potent derivatives, setting the stage for
their modern use in clinical settings. While initially intended to combat muscle wasting, anabolic
steroids have since been repurposed and are now approved for specific
therapeutic uses.

## Bookshelf
StatPearls is a valuable resource available through the NCBI Bookshelf,
offering concise yet comprehensive information on various clinical topics.
Accessible via the NCBI website, StatPearls serves as a trusted repository of evidence-based medical knowledge,
ideal for healthcare professionals seeking quick and
reliable references.

## Anabolic Steroids
Anabolic steroids are synthetic derivatives of testosterone that possess
both anabolic (growth-promoting) and androgenic (masculinizing) properties.
Their mechanism of action involves binding to androgen receptors, activating gene expression pathways that enhance muscle protein synthesis and fat metabolism.

## Authors & Affiliations
Contributions come from esteemed researchers and clinicians
across various fields, including endocrinology and pharmacology.
Notable affiliations include institutions contributing to the content’s accuracy and reliability.

## Continuing Education Activity
StatPearls functions as a continuing education resource, offering courses and materials that
aid medical professionals in staying updated with
clinical knowledge and practices.

## Indications
Approved uses of anabolic steroids include treating muscle wasting, osteoporosis,
and certain metabolic disorders. Despite their efficacy, off-label use
is common, often for performance enhancement, despite
regulatory restrictions to prevent misuse.

## Mechanism of Action
Anabolic steroids affect target tissues via both genomic and non-genomic pathways, influencing processes like protein synthesis and
fat redistribution, thereby promoting muscle growth and recovery.

## Administration
Available in oral and injectable forms, dosages
vary based on specific indications, with careful consideration of individual patient factors to optimize treatment outcomes.

## Adverse Effects
Use of anabolic steroids can lead to severe adverse effects, including
hepatotoxicity, cardiovascular risks, and psychiatric issues,
necessitating close monitoring and patient education.

## Contraindications
Conditions such as liver disease or certain cardiovascular issues
contraindicate anabolic steroid use, highlighting the importance of comprehensive patient history assessment.

## Monitoring
Regular monitoring includes lab tests for liver function and cholesterol levels to early detect adverse effects, ensuring patient safety and treatment efficacy.

## Toxicity
Both acute overdose and chronic misuse can lead to severe health complications, underscoring
the need for emergency care and addiction prevention strategies.

## Enhancing Healthcare Team Outcomes
Effective team collaboration improves patient management, with shared decision-making enhancing outcomes while addressing
ethical considerations related to steroid use.

## Review Questions
Engage with multiple-choice questions covering mechanisms, uses, and risks to test comprehensive understanding of anabolic steroid applications and associated challenges.

## References
Key references from StatPearls or reputable journals provide evidence-based support for the
information presented, ensuring reliable clinical guidance.

## Views
Perspectives on anabolic steroids vary, with society weighing
ethical concerns against medical benefits. This discussion is crucial for balanced consideration of their use
in clinical settings.

## Bulk Download
Access StatPearls content via bulk download, enabling offline reference for convenient
review and application in clinical practice.

## Related Information
Explore additional resources on PubMed to expand knowledge on steroid uses
beyond the provided context, aiding deeper understanding of clinical applications.

## Similar Articles in PubMed
Find related articles to extend your knowledge base, connecting steroid use with broader medical topics for comprehensive learning.

## Recent Activity
Stay updated with new research and guidelines on anabolic steroids through recent activity feeds, ensuring informed clinical practice aligned with current developments.

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